Terumo Cardiovascular Systems

ocs header image
optimizing cardiac surgery
e-mail usprint

Leukocycte Filters

Leukocyte reduction during cardiac surgery is associated with a number of positive patient outcomes.

Information provided on this website is not intended to make claims that the products are safe and effective for any use other than those explicitly described in the Instructions for Use. Clinicians should refer to the Instructions for Use or Owner's Manuals for complete information on the intended use of any product mentioned in this website.

STUDY: Aprotinin and Leukocyte Filtration Reduces Post-Operative Atrial Fibrillation
Albert O-Yurvati, DO, presented a study at the July 2006 Hammersmith Meeting showing the impact of leukocyte filtration and aprotinin on reducing post-op Afib.
CDROM: Non-Pharmacologic Therapeutic Strategies for Reducing Complications of Cardiopulmonary Bypass
Serdar Gunaydin, MD, PhD, presents clinically significant results using XCoating™ and leukocyte filtration for high-risk patients at the May 2006 Optimizing Cardiac Surgery Symposium.
CDROM: Leukocyte Filtration and the Multiple Modality Approach of Anti-Inflammatory Strategy
Order a complimentary CDROM of the New Orleans Optimizing Cardiac Surgery Symposium (April 2005) to watch Steve Sutton CCP's presentation on the benefits of continuous leukocyte filtration.
CDROM: Benefits of Leukocyte Filtration for CPB
Amit Patel, MD, presents leukocyte filtration strategies at the Orlando 2006 Optimizing Cardiac Surgery Symposium.
CDROM: Leukocyte Filtration: Can this Technology Improve Outcomes in Cardiac Surgery?
Albert O-Yurvati, DO, presents his work with leukocyte filtration at the 2006 Optimizing Cardiac Surgery Symposium.
ABSTRACT: Intraoperative Treatment Strategy to Reduce the Incidence of Post-Cardiopulmonary Bypass Atrial Fibrillation. Perfusion 2002; V 17. O-Yurvati A.
In this study, the authors demonstrate a 72% reduction in the incidence of post-op atrial fibrillation in patients who receive leukocyte filtration and aprotinin, resulting in $8,725 savings per patient.
ABSTRACT: Non-Pharmacologic Therapeutic Strategies for Reducing Complications of Cardiopulmonary Bypass. Filtration 2005; 1(2):95-106. Gunaydin S, et al.
This study of 225 patients undergoing CPB concludes that the use of circuits with leukocyte filtration and X Coatingâ?¢ provides clinically significant benefits for high risk patients.
ABSTRACT: Leukocyte Filtration and Aprotinin: Synergistic Anti-Inflammatory Protection. Perfusion 2004; Volume 19. O-Yurvati A.
In this follow-up study, Albert O-Yurvati, DO, compares the effects of leukocyte filtration combined with aprotinin versus aprotinin alone to reduce post-operative atrial fibrillation in patients undergoing CPB.
ABSTRACT: Clinical Evaluation of a Leuko-Depleting Blood Cardioplegia Filter (BC1B) for Elective Open-Heart Surgery. Perfusion 1998; 13: 205-210. Suzuki, et al.
In this study of 40 CABG patients, the authors demonstrate the ability of the Pall BC1 filter to remove inflammatory mediators CPK-MB and troponin.
ABSTRACT: Neutrophil Depletion Reduces Myocardial Reperfusion Morbidity. Annals of Thoracic Surgery. March 2004; 77: 956-961. Palatianos, et al.
In this study of 160 patients, the authors demonstrated that neutrophil filtered blood cardioplegia significantly reduced biochemical markers of myocardial reperfusion injury.
ABSTRACT: A Review of Leukofiltration in Cardiac Surgery: The Time Course of Reperfusion Injury may Facilitate Study Design of Anti-Inflammatory Effects. Perfusion 2002; 17: 53-62. Ortolano, et al.
The authors address the effects of systemic inflammatory response syndrome (SIRS) during CPB, and provide a review of leukocyte filtration literature.
ABSTRACT: Clinical Benefits of Continuous Leukocyte Filtration during Cardiopulmonary Bypass in Patients undergoing Valvular Repair or Replacement. Perfusion 2005; V 20: 21-9. Sutton S, et al.
In this retrospective study of 700 patients undergoing valve surgery, the authors demonstrate significant benefits to patients who receive leukocyte filtration, including reduced time to extubation and reduced LOS.
ABSTRACT: Evaluation of Leukocyte-Depleted Terminal Blood Cardioplegia Solution in Patients Undergoing Elective and Emergency Coronary Artery Bypass Grafting. Journal of Thoracic and Cardiovascular Surgery. 1994;108, 6:1125-3. Sawa, et al.
The authors demonstrate leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in patients undergoing aortic cross-clamping for more than 120 minutes.
ABSTRACT: Modifying Risk for Extracorporeal Circulation: Trial of Four Anti-inflammatory Strategies. Annals of Thoracic Surgery, 1998; 66:747-754. Gott, et al.
This 400-patient study of patients undergoing CPB show a reduced length of stay and reduced hospital charges up to $6,000 in low risk patients who receive leukocyte filtration.
ABSTRACT: Cost Effectiveness of Using a Leuko-Depleting Arterial Line Filter. Proceedings of the American Academy of Cardiovascular Perfusion 1994: v 15. Palanzo D, et al.
In this study of 350 patients, the authors conclude that the use of the Pall LG6 filter improves post-bypass lung function, and results in $1,942 savings per patient.
ABSTRACT: Strategic Leukocyte Depletion Reduces Pulmonary Microvascular Pressure and Improves Pulmonary Status Post-Cardiopulmonary Bypass. Perfusion 2003; Volume 18. O-Yurvati A.
Albert O-Yurvati, DO, demonstrates the combination of leukocyte filtration and aprotinin in reducing pulmonary microvascular pressure and shunt fraction in a study of 225 CABG patients.
ABSTRACT: Clinical Effectiveness of Leukocyte Filtration During Cardiopulmonary Bypass in Patients With Chronic Obstructive Pulmonary Disease. Ann Thorac Surg 2004; 78:1339-44. Karaiskos, et al.
In this study of COPD patients undergoing CPB, the authors conclude that the use of the Pall LG6 filter results in improved respiratory index, shorter ICU and hospital LOS.
ABSTRACT: The Effect of Leukocyte-Depleting Arterial Line Filters on Cerebral Microemboli and Neuropsychological Outcome following Coronary Artery Bypass Surgery. Eur J Cardiothorac Surg 2004; Feb;25(2):267-74. Whittaker, et al
The authors evaluate the effect of using the Pall LG6 arterial line filter on cerebral microemboli and neuropsychological outcome following bypass surgery.
ABSTRACT: The Role of Leukocyte Depleting Filters in Heart Transplantation: Early Outcomes in Prospective, Randomized Clinical Trial. European Journal of Cardiothoracic Surgery. October 2006; 30: 621-627. Dvorak, et al.
In this study of 40 patients, the authors find leukocyte filtration reduces markers of reperfusion injury, time on ventilation and time in the ICU, and improves graft functionality.